Pharmaceutical synthesis tail gas compression condensation membrane separation and recovery complete set of equipment, professional manufacturer Luoyang Wo Hong Petrochemical.

In the pharmaceutical synthesis process, operations such as reactor pressure relief, liquid–liquid extraction, distillation for solvent removal, vacuum drying, and material transfer continuously release process exhaust gases, which contain a mixture of various organic solvents including dichloromethane, acetone, ethyl acetate, tetrahydrofuran, and alcohols. Pharmaceutical synthesis generally adopts batch intermittent production mode, exhaust emissions are not continuous, the concentration of exhaust gas in the reaction feeding stage is rapidly high, the concentration of equipment standby stage is rapidly falling, and the fluctuation range of working conditions is large. The exhaust gas stream is entrained with material fine mist, suspended impurities and saturated water vapor. Halogenated solvents will undergo hydrolysis reaction after contacting water vapor to generate acidic substances, which will cause continuous corrosion to pipes and equipment. Most organic components are flammable and explosive media, which have strict requirements on the corrosion resistance, safety protection capability and working condition adaptability of the whole recovery device. Traditionwaste gas treatmentIt is difficult to balance emission compliance, solvent resource recovery and production site safety at the same time, and it has been difficult to match the actual operating conditions of the pharmaceutical synthesis plant.

Although the incineration process can realize tail gas purification, it will directly incinerate a large amount of organic solvents with use value, resulting in a large amount of loss of raw materials. After high-temperature incineration of tail gas containing halogenated components, it is also easy to generate toxic and corrosive by-products. Subsequent pipelines will be eroded, and complex tail gas post-treatment systems need to be built. Equipment investment and long-term operation and maintenance costs remain high.activated charcoalAdsorption is a pollutant transfer treatment method, and solvent recovery cannot be completed. Under the conditions of multi-component, high humidity and frequent concentration fluctuation of exhaust gas, the adsorption material is easily saturated in advance, adsorption penetration occurs, frequent shutdown is required to replace adsorption consumables, hazardous waste output is very large, and enterprises need to bear high expenditure on consumables procurement and hazardous waste disposal. The simple condensation process relies on low temperature to achieve solvent liquefaction recovery, subject to the organic vapor partial pressure conditions, only in the high concentration range recovery effect is better, in the face of the concentration of fluctuations in the pharmaceutical synthetic exhaust gas, the overall recovery efficiency is unstable, low concentration conditions treatment effect has obvious short board.

The compression condensation film coupling process adopts a purely physical treatment route, and the whole process does not undergo combustion and chemical reactions, which is very suitable for the complex treatment requirements of pharmaceutical synthesis tail gas. The tail gas first enters the pretreatment unit, and relies on the multi-stage filtering and defoaming structure to remove liquid droplets, fine solid impurities and free moisture carried by the airflow, so as to prevent impurities from entering the back-end core unit and causing blockage damage. The tail gas after purification treatment is sent to the compression unit, the partial pressure of organic vapor is increased, the solvent liquefaction conditions are optimized, and then sent to the multi-stage gradient condensation module, gradient cooling is carried out according to the difference of boiling points of various solvents, most organic solvents are directly liquefied and separated, and the preliminary solvent recovery is completed.

After condensation treatment, the remaining tail gas still carries part of the organic solvent and will be sent to the organic membrane separation unit to complete the enrichment and separation of solvent components based on the selective permeability difference between the organic solvent and air of the membrane material. The treated tail gas is discharged outward, and the enriched high-concentration organic gas stream flows back to the inlet of the compressor, and then enters the whole system for circulating treatment again. The closed-loop operation mode fully exploits the solvent recovery potential. After precipitation, filtration and testing, the recovered organic solvent can be reused in the synthesis process after the indicators meet the production requirements, and the solvent resources lost in the tail gas can be recycled and reused, so as to reduce the amount of hazardous waste generated from the source and reduce the double cost of raw material procurement and hazardous waste disposal.

In view of the working conditions of pharmaceutical synthetic tail gas, the device configuration design must conform to the actual conditions of the site. The pipes, valves and heat exchange components in contact with the exhaust gas are made of corrosion-resistant materials to resist the acid corrosion caused by the hydrolysis of halogenated media and ensure the stable operation of the equipment for a long time. The whole device is equipped with complete overpressure, overtemperature, medium leakage monitoring and automatic interlocking protection mechanism to avoid various safety risks under flammable and explosive conditions. The automatic control system is equipped with a frequency conversion adjustment mechanism, which can respond to drastic changes in exhaust gas air volume and concentration in real time, automatically adjust the operating load of the equipment, adapt to fluctuations in working conditions brought about by batch production, avoid overload operation or invalid idling of the equipment, and control the overall energy consumption level. The pre-pretreatment system intercepts all kinds of impurity droplets in stages, forms effective protection for precision parts such as heat exchangers and membrane modules, and prolongs the service life of the device. Process design requires the collection of on-site measured waste gas air volume, component composition, concentration range, water content and impurity data to carry out customized accounting, and cannot directly apply general models, so as to ensure the stable compliance of VOCs waste gas treatment and effectively achieve the goal of organic solvent resource recovery and cost reduction.